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Article

Multi-omics study revealing the complexity and spatial heterogeneity of tumor-infiltrating lymphocytes in primary liver carcinoma.

Oncotarget - 23 May 2017

Shi Lijun, Zhang Yang, Feng Lin, Wang Liming, Rong Weiqi, Wu Fan, Wu Jianxiong, Zhang Kaitai, Cheng Shujun

Abstract excerpt

Intratumoral heterogeneity has been revealed in primary liver carcinoma (PLC). However, spatial heterogeneity of tumor-infiltrating lymphocytes (TILs), which reflects one dimension of a tumor's spatial heterogeneity, and the relationship between TIL diversity, local immune response and mutation burden remain unexplored in PLC. Therefore, we performed immune repertoire sequencing, gene expression profiling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell

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Identifiers

PMID: 28422742
DOI: 10.18632/oncotarget.16758
PMCID: PMC5471016

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