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HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4 + T Cells

15 Jan 2020

Abstract excerpt

HIV infection modulates the surface expression of Tim-3, but the molecular determinants remain poorly understood. Here, we show that HIV-1 Vpu downregulates Tim-3 from the surface of infected primary CD4 + T cells through its transmembrane domain and alters its subcellular localization. Tim-3 blockade increases HIV-1 replication, suggesting a potential negative role of this protein in viral spread that is...

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Identifiers

PMID: 31941771
DOI: 10.1128/jvi.01999-19

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