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Article

HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation.

Virology - 30 Mar 2008

Okumura Atsushi, Alce Tim, Lubyova Barbora, Ezelle Heather, Strebel Klaus, Pitha Paula M

Abstract excerpt

The activation of IRF-3 during the early stages of viral infection is critical for the initiation of the antiviral response; however the activation of IRF-3 in HIV-1 infected cells has not yet been characterized. We demonstrate that the early steps of HIV-1 infection do not lead to the activation and nuclear translocation of IRF-3; instead, the relative levels of IRF-3 protein are decreased due to the...

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Identifiers

PMID: 18082865
DOI: 10.1016/j.virol.2007.10.042
PMCID: PMC2312338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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