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Article

The Physiological Relevance of CD4 Receptor Down-Modulation During HIV Infection

1 Apr 2003

Abstract excerpt

Upon binding to the CD4 receptor the HIV envelope protein undergoes conformational changes that culminate in the fusion of the viral and cellular membranes. A few hours later, a sophisticated set of processes is initiated to ensure the down-modulation of the viral receptor. Three viral proteins participate in this process: Nef, Env, and Vpu, suggesting that this function is critical for virus replication. The...

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Identifiers

PMID: 15043201
DOI: 10.2174/1570162033485276

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