Article
Vpu Is the Main Determinant for Tetraspanin Downregulation in HIV-1-Infected Cells
8 Jan 2015
Abstract excerpt
UNLABELLED: Tetraspanins constitute a family of cellular proteins that organize various membrane-based processes. Several members of this family, including CD81, are actively recruited by HIV-1 Gag to viral assembly and release sites. Despite their enrichment at viral exit sites, the overall levels of tetraspanins are decreased in HIV-1-infected cells. Here, we identify Vpu as the main viral determinant for...