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Article

Uncovering axes of variation among single-cell cancer specimens.

Nature methods - 1 Mar 2020

Chen William S, Zivanovic Nevena, van Dijk David, Wolf Guy, Bodenmiller Bernd, Krishnaswamy Smita

Abstract excerpt

While several tools have been developed to map axes of variation among individual cells, no analogous approaches exist for identifying axes of variation among multicellular biospecimens profiled at single-cell resolution. For this purpose, we developed 'phenotypic earth mover's distance' (PhEMD). PhEMD is a general method for embedding a 'manifold of manifolds', in which each datapoint in the higher-level...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31932777
DOI: 10.1038/s41592-019-0689-z
PMCID: PMC7339867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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