Article

Geostatistical Modeling and Heterogeneity Analysis of Tumor Molecular Landscape

2022-09-26

Abstract excerpt

Intratumor heterogeneity (ITH) is associated with therapeutic resistance and poor prognosis in cancer patients, and attributed to genetic, epigenetic, and microenvironmental factors. We developed a new computational platform, GATHER, for geostatistical modeling of single cell RNA-seq data to synthesize high-resolution and continuous gene expression landscapes of a given tumor sample. Such landscapes allow GATHER t...

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Literature Corpus work: a4a01a81-a73a-5c13-8471-72389ea60623
DOI: 10.20944/preprints202209.0388.v1

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