Article

Quantifying Pathological Progression from Single-Cell Data

2024-12-03

Abstract excerpt

The surge in single-cell datasets and reference atlases has enabled the comparison of cell states across conditions, yet a gap persists in quantifying pathological shifts from healthy cell states. To address this gap, we introduce single-cell Pathological Shift Scoring (scPSS) which provides a statistical measure for how much a “query” cell from a diseased sample has been shifted away from a reference group of hea...

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Literature Corpus work: b5fcd948-b119-5c5f-9941-47e3c33370ee
DOI: 10.1101/2024.11.27.625593

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