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Article

Interaction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke.

Neurology - 17 Mar 2020

Qin Xianhui, Spence J David, Li Jianping, Zhang Yan, Li Youbao, Sun Ningling, Liang Min, Song Yun, Zhang Yuanyuan, Wang Binyan, Cheng Xiaoshu, Zhao Lianyou, Wang Xiaobin, Xu Xiping, Huo Yong

Abstract excerpt

OBJECTIVE: We evaluated the interaction of serum folate and vitamin B12 with methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on the risk of first ischemic stroke and on the efficacy of folic acid treatment in prevention of first ischemic stroke. METHODS: A total of 20,702 hypertensive adults were randomized to a double-blind treatment of daily enalapril 10 mg and folic acid 0.8 mg or enalapril 10 mg...

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Identifiers

PMID: 31932513
DOI: 10.1212/WNL.0000000000008932
PMCID: PMC7220236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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