Article
A potential epigenetic marker mediating serum folate and vitamin B12 levels contributes to the risk of ischemic stroke.
BioMed research international - 1 Jan 2015
Wei Loo Keat, Sutherland Heidi, Au Anthony, Camilleri Emily, Haupt Larisa M, Gan Siew Hua, Griffiths Lyn R
Abstract excerpt
Stroke is a multifactorial disease that may be associated with aberrant DNA methylation profiles. We investigated epigenetic dysregulation for the methylenetetrahydrofolate reductase (MTHFR) gene among ischemic stroke patients. Cases and controls were recruited after obtaining signed written informed consents following a screening process against the inclusion/exclusion criteria. Serum vitamin profiles (folate,...
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