Article
The Association of Modifiable Breast Cancer Risk Factors and Somatic Genomic Alterations in Breast Tumors: The Cancer Genome Atlas Network.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2020
Heng Yujing J, Hankinson Susan E, Wang Jun, Alexandrov Ludmil B, Ambrosone Christine B, de Andrade Victor P, Brufsky Adam M, Couch Fergus J, King Tari A, Modugno Francesmary, Vachon Celine M, Eliassen A Heather, Tamimi Rulla M, Kraft Peter
Abstract excerpt
BACKGROUND: The link between modifiable breast cancer risk factors and tumor genomic alterations remains largely unexplored. We evaluated the association of prediagnostic body mass index (BMI), cigarette smoking, and alcohol consumption with somatic copy number variation (SCNV), total somatic mutation burden (TSMB), seven single base substitution (SBS) signatures (SBS1, SBS2, SBS3, SBS5, SBS13, SBS29, and SBS30),...
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