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Article

Somatic Mutation Profiling and Therapeutic Landscape of Breast Cancer in the MENA Region.

Cells - 14 Nov 2025

Velayutham Dinesh, Elango Ramesh, Rashid Sameera, Al-Sarraf Reem, Akhtar Mohammed, Ouararhni Khalid, Jithesh Puthen Veettil, Alajez Nehad M

Abstract excerpt

Breast cancer remains a major global health challenge. Yet, genomic data from Middle Eastern and North African (MENA) populations are limited, restricting insights into disease drivers and therapeutic opportunities in this demographic. To address this gap, we performed whole-exome sequencing (WES) on 52 breast cancer samples, including 51 from the MENA region, to characterize somatic mutations and potential...

Read the complete abstract on PubMed

Topics

Humans
Breast Neoplasms
Female
Mutation
Africa, Northern
Exome Sequencing
Middle East

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 41294844
DOI: 10.3390/cells14221791
PMCID: PMC12651733

Genes

TP53
ATM
BRCA2
ERCC2
ERCC3
GATA3
KMT2C
MLH1
MSH2
PIK3CA
PTEN
RAD51C
SF3B1

Provenance

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