Article
Age dependent association of inbreeding with risk for schizophrenia in Egypt.
Schizophrenia research - 1 Feb 2020
McClain Lora, Mansour Hader, Ibrahim Ibtihal, Klei Lambertus, Fathi Warda, Wood Joel, Kodavali Chowdari, Maysterchuk Alina, Wood Shawn, El-Chennawi Farha, Ibrahim Nahed, Eissa Ahmed, El-Bahaei Wafaa, El Sayed Hanan, Yassein Amal, Tobar Salwa, El-Boraie Hala, El-Sheshtawy Eman, Salah Hala, Ali Ahmed, Erdin Serkan, Devlin Bernie, Talkowski Michael, Nimgaonkar Vishwajit
Abstract excerpt
BACKGROUND: Self-reported consanguinity is associated with risk for schizophrenia (SZ) in several inbred populations, but estimates using DNA-based coefficients of inbreeding are unavailable. Further, it is not known whether recessively inherited risk mutations can be identified through homozygosity by descent (HBD) mapping. METHODS: We studied self-reported and DNA-based estimates of inbreeding among Egyptian...
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