Article
Does telomere length mediate associations between inbreeding and increased risk for bipolar I disorder and schizophrenia?
Psychiatry research - 30 Jun 2011
Mansour Hader, Chowdari Kodavali, Fathi Warda, Elassy Mai, Ibrahim Ibtihal, Wood Joel, Bamne Mikhil, Tobar Salwa, Yassin Amal, Salah Hala, Elsayed Hanan, Eissa Ahmed, El-Boraie Hala, Ibrahim Nahed E, Elsayed Mohamed, El-Bahaei Wafaa, Gomaa Zeinab, El-Chennawi Farha, Nimgaonkar Vishwajit L
Abstract excerpt
We have recently found that consanguinity is a risk factor for bipolar I disorder (BP1) and schizophrenia (SZ) in Egypt. Inbreeding has been associated with increased cellular stress and impaired physiological function in plants and animals. Previous studies have reported that telomere length (TL), an index of oxidative stress and cellular senescence is significantly reduced among patients with SZ or mood...
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