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Associations between mosaic loss and schizophrenia or bipolar disorder of young age.

Molecular psychiatry - 1 May 2026

Uchiyama Shunsuke, Saito Takeo, Liu Xiaoxi, Ishikawa Yuki, Hikino Keiko, Ikeda Masashi, Genovese Giulio, Iwata Nakao, Terao Chikashi

Abstract excerpt

Mosaic chromosomal alterations (mCAs) accumulate in the brain tissues and are associated with psychiatric disorders. The association between mCAs in circulating blood and schizophrenia (SCZ) and bipolar disorders (BD) has not been fully evaluated. We detected mCAs from blood samples in 2470 SCZ, 3732 BD, and 177,773 control subjects. The associations between mCAs and SCZ or BD were evaluated using age-adjusted...

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PMID: 41535559
DOI: 10.1038/s41380-025-03397-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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