The Number of Signaling Pathways Altered by Driver Mutations in Chronic Lymphocytic Leukemia Impacts Disease Outcome.

doi:10.1158/1078-0432.CCR-18-4158

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Article

The Number of Signaling Pathways Altered by Driver Mutations in Chronic Lymphocytic Leukemia Impacts Disease Outcome.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2020

Brieghel Christian, da Cunha-Bang Caspar, Yde Christina Westmose, Schmidt Ane Yde, Kinalis Savvas, Nadeu Ferran, Andersen Michael Asger, Jacobsen Line Offenbach, Andersen Mette Klarskov, Pedersen Lone Bredo, Delgado Julio, Baumann Tycho, Mattsson Mattias, Mansouri Larry, Rosenquist Richard, Campo Elias, Nielsen Finn Cilius, Niemann Carsten Utoft

Abstract excerpt

PURPOSE: Investigation of signaling pathways altered by recurrent gene mutations and their clinical impact in a consecutive cohort of patients with newly diagnosed chronic lymphocytic leukemia (CLL). The heterogeneous clinical course and genetic complexity of CLL warrant improved molecular prognostication. However, the prognostic value of recurrent mutations at the time of diagnosis remains unclear. EXPERIMENTAL...

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PMID: 31919133
DOI: 10.1158/1078-0432.CCR-18-4158

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