Article
The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia.
Seminars in cancer biology - 1 Oct 2015
Sutton Lesley-Ann, Rosenquist Richard
Abstract excerpt
With the advent of next-generation sequencing, the mutational landscape of chronic lymphocytic leukemia (CLL) was rapidly unraveled with the discovery of recurrently mutated genes affecting key signaling pathways. Although the majority of these mutations are relatively infrequent at diagnosis (at least at the population-level) they tend to accumulate as the disease progresses or at relapse. Besides TP53...
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