Article
New drug discovery approaches targeting recurrent mutations in chronic lymphocytic leukemia.
Expert opinion on drug discovery - 1 Oct 2017
Tripathi Rupal, Lee-Verges Eriong, Higashi Morihiro, Gimenez Neus, Rosich Laia, Lopez-Guerra Monica, Colomer Dolors
Abstract excerpt
INTRODUCTION: Next generation sequencing has provided a comprehensive understanding of the mutational landscape in chronic lymphocytic leukemia (CLL), and new drivers have been identified. Some of these drivers could be pharmacologically targeted to choose the most effective personalized therapy in each CLL patient. Areas covered: In this article, the authors uncover the potential role of new targeted therapies...
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