Article
Predictive metabolic networks reveal sex- and APOE genotype-specific metabolic signatures and drivers for precision medicine in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2023
Chang Rui, Trushina Eugenia, Zhu Kuixi, Zaidi Syed Shujaat Ali, Lau Branden M, Kueider-Paisley Alexandra, Moein Sara, He Qianying, Alamprese Melissa L, Vagnerova Barbora, Tang Andrew, Vijayan Ramachandran, Liu Yanyun, Saykin Andrew J, Brinton Roberta D, Kaddurah-Daouk Rima
Abstract excerpt
INTRODUCTION: Late-onset Alzheimer's disease (LOAD) is a complex neurodegenerative disease characterized by multiple progressive stages, glucose metabolic dysregulation, Alzheimer's disease (AD) pathology, and inexorable cognitive decline. Discovery of metabolic profiles unique to sex, apolipoprotein E (APOE) genotype, and stage of disease progression could provide critical insights for personalized LOAD...
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