Article

Deficiency of IKKβ in neurons ameliorates Alzheimer’s disease pathology in APP- and tau-transgenic mice

2022-06-02

Abstract excerpt

<h4>Background: </h4> Alzheimer’s disease (AD) is pathologically characterized by extracellular deposition of amyloid β peptide (Aβ), intracellular neurofibrillary tangles (composed mainly of phosphorylated tau [p-tau]) and neuroinflammation. The pathogenic role of inflammatory activation in AD has been extensively studied; however, the underlying mechanisms remain unclear. In this project, we investigated how neu...

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Literature Corpus work: a7a426fe-b5b9-5818-ac85-405034a8d4c3
DOI: 10.21203/rs.3.rs-1696103/v1

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