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Article

Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies.

ACS chemical neuroscience - 21 Nov 2018

McKenzie-Nickson Simon, Chan Jacky, Perez Keyla, Hung Lin W, Cheng Lesley, Sedjahtera Amelia, Gunawan Lydia, Adlard Paul A, Hayne David J, McInnes Lachlan E, Donnelly Paul S, Finkelstein David I, Hill Andrew F, Barnham Kevin J

Abstract excerpt

Alzheimer's disease (AD) is the leading cause of dementia worldwide accounting for around 70% of all cases. There is currently no treatment for AD beyond symptom management and attempts at developing disease-modifying therapies have yielded very little. These strategies have traditionally targeted the peptide Aβ, which is thought to drive pathology. However, the lack of clinical translation of these Aβ-centric...

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PMID: 29920069
DOI: 10.1021/acschemneuro.8b00161

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APP
CDK5

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