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Article

Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice.

Neuroscience - 16 Jun 2009

Zhang X, Luhrs K J, Ryff K A, Malik W T, Driscoll M J, Culver B

Abstract excerpt

Neuroinflammation has been linked to the pathologies of Alzheimer's disease (AD), however, its effects on beta-amyloid (Abeta) burden are unclear. This study investigated the role of nuclear factor kappa B (NF-kappaB) in regulating neuroinflammation and Abeta deposition in a transgenic mouse model of AD. The APPswe/PS1dE9 mice and their wild-type controls received either the NF-kappaB inhibitor pyrrolidine...

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PMID: 19286451
DOI: 10.1016/j.neuroscience.2009.03.010

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