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Article

Intraflagellar-transport A dysfunction causes hyperphagia-induced systemic insulin resistance in a pre-obese state.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2020

Jacobs Damon T, Allard Bailey A, Pottorf Tana S, Silva Luciane M, Wang Wei, Al-Naamani Aisha, Agborbesong Ewud, Wang Tao, Carr Dajanae A, Tran Pamela V

Abstract excerpt

Deletion of murine Thm1, an intraflagellar transport A (IFT-A) component that mediates ciliary protein trafficking, causes hyperphagia, obesity, and metabolic syndrome. The role of Thm1 or IFT-A in adipogenesis and insulin sensitivity is unknown. Here, we report that Thm1 knockdown in 3T3-L1 pre-adipocytes promotes adipogenesis and enhances insulin sensitivity in vitro. Yet, pre-obese Thm1 conditional knockout...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31914634
DOI: 10.1096/fj.201900751R
PMCID: PMC7278885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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