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Article

Alström syndrome: insights into the pathogenesis of metabolic disorders.

Nature reviews. Endocrinology - 1 Feb 2011

Girard Dorothée, Petrovsky Nikolai

Abstract excerpt

Genetic causes of obesity include the ciliopathies Alström syndrome and Bardet-Biedl syndrome. In these disorders, mutations cause dysfunction of the primary cilium, an organelle involved in intracellular and intercellular sensing and signaling. Alström syndrome is an autosomal-recessive disorder...

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Identifiers

PMID: 21135875
DOI: 10.1038/nrendo.2010.210

Genes

ALMS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21135875-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Alström syndrome: insights into the pathogenesis of metabolic disorders.PMID 21135875Read ↗

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The cilium: a cellular antenna with an influence on obesity risk.Semantic proximity Read ↗

Bardet‐Biedl syndrome: A focus on genetics, mechanisms and metabolic dysfunctionSemantic proximity Read ↗

Mechanisms of Weight Control by Primary CiliaSemantic proximity Read ↗

A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice.Semantic proximity Read ↗

Genomic knockout of <i>alms1</i> in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypesSemantic proximity Read ↗

Knockdown of the Alström syndrome-associated gene Alms1 in 3T3-L1 preadipocytes impairs adipogenesis but has no effect on cell-autonomous insulin action.Semantic proximity Read ↗

Utilization of conditional alleles to study the role of the primary cilium in obesity.Semantic proximity Read ↗

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