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Article

Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance.

Diabetes - 1 Feb 2021

Geberhiwot Tarekegn, Baig Shanat, Obringer Cathy, Girard Dorothée, Dawson Charlotte, Manolopoulos Konstantinos, Messaddeq Nadia, Bel Lassen Pierre, Clement Karine, Tomlinson Jeremy W, Steeds Richard P, Dollfus Hélène, Petrovsky Nikolai, Marion Vincent

Abstract excerpt

Obesity is a major risk factor for insulin resistance (IR) and its attendant complications. The pathogenic mechanisms linking them remain poorly understood, partly due to a lack of intermediary monogenic human phenotypes. Here, we report on a monogenic form of IR-prone obesity, Alström syndrome (ALMS). Twenty-three subjects with monogenic or polygenic obesity underwent hyperinsulinemic-euglycemic clamping with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32994277
DOI: 10.2337/db20-0647
PMCID: PMC7881858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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