Article
Radiation-induced germline mutations detected by a direct comparison of parents and first-generation offspring DNA sequences containing SNPs.
Mutation research - 11 Apr 2006
Wu Jianyu, Morimyo Mitsuoki, Hongo Etsuko, Higashi Tomoyasu, Okamoto Masanori, Kawano Akihiro, Ohmachi Yasushi
Abstract excerpt
Germline mutation induction has been detected in mice but not in humans. To estimate the genetic risk of germline mutation induction in humans, new techniques for extrapolating from animal data to humans or directly detecting radiation-induced mutations in man are expected to be developed. We have developed a new method to detect germline mutations by directly comparing the DNA sequences of parents and...
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