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Article

Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions.

Nature communications - 8 Jan 2020

Ibarra Ignacio L, Hollmann Nele M, Klaus Bernd, Augsten Sandra, Velten Britta, Hennig Janosch, Zaugg Judith B

Abstract excerpt

Recent high-throughput transcription factor (TF) binding assays revealed that TF cooperativity is a widespread phenomenon. However, a global mechanistic and functional understanding of TF cooperativity is still lacking. To address this, here we introduce a statistical learning framework that provides structural insight into TF cooperativity and its functional consequences based on next generation sequencing data....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31913281
DOI: 10.1038/s41467-019-13888-7
PMCID: PMC6949242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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