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Article

Cooperative transcription factor associations discovered using regulatory variation.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2011

Karczewski Konrad J, Tatonetti Nicholas P, Landt Stephen G, Yang Xinqiong, Slifer Teri, Altman Russ B, Snyder Michael

Abstract excerpt

Regulation of gene expression at the transcriptional level is achieved by complex interactions of transcription factors operating at their target genes. Dissecting the specific combination of factors that bind each target is a significant challenge. Here, we describe in detail the Allele Binding Cooperativity test, which uses variation in transcription factor binding among individuals to discover combinations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21828005
DOI: 10.1073/pnas.1103105108
PMCID: PMC3156166

Genes

EBF1
STAT1

Provenance

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