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Article

Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation.

Cancer research - 1 Mar 2020

Zhang Fan, Lou Lihong, Peng Bo, Song Xiaotian, Reizes Ofer, Almasan Alexandru, Gong Zihua

Abstract excerpt

53BP1 controls two downstream subpathways, one mediated by PTIP and Artemis and the other by RIF1 and MAD2L2/Shieldin, to coordinate DNA repair pathway choices. However, the upstream regulator(s) of 53BP1 function in DNA repair remain unknown. We and others recently reported that TIRR associates with 53BP1 to stabilize it and prevents 53BP1 localization to DNA damage sites by blocking 53BP1 Tudor domain binding...

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Identifiers

PMID: 31911551
DOI: 10.1158/0008-5472.CAN-19-2205
PMCID: PMC7056578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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