Article
The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.
Nucleic acids research - 18 Sept 2020
Geng Anke, Tang Huanyin, Huang Jin, Qian Zhen, Qin Nan, Yao Yunxia, Xu Zhu, Chen Hao, Lan Li, Xie Hongjuan, Zhang Jian, Jiang Ying, Mao Zhiyong
Abstract excerpt
The NAD+-dependent deacetylase and mono-ADP-ribosyl transferase SIRT6 stabilizes the genome by promoting DNA double strand break repair, thereby acting as a tumor suppressor. However, whether SIRT6 regulates nucleotide excision repair (NER) remains unknown. Here, we showed that SIRT6 was recruited to sites of UV-induced DNA damage and stimulated the repair of UV-induced DNA damage. Mechanistic studies further...
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