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Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

10 Apr 2012

Abstract excerpt

The cellular DNA damage response (DDR) machinery that maintains genomic integrity and prevents severe pathologies, including cancer, is orchestrated by signaling through protein modifications. Protein ubiquitylation regulates repair of DNA double-strand breaks (DSBs), toxic lesions caused by various metabolic as well as environmental insults such as ionizing radiation (IR). Whereas several components of the...

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PMID: 22456334
DOI: 10.4161/cc.19978

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