Article
Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR.
Nature communications - 12 Jul 2018
Wang Jiaxu, Yuan Zenglin, Cui Yaqi, Xie Rong, Yang Guang, Kassab Muzaffer A, Wang Mengxi, Ma Yinliang, Wu Chen, Yu Xiaochun, Liu Xiuhua
Abstract excerpt
53BP1 performs essential functions in DNA double-strand break (DSB) repair and it was recently reported that Tudor interacting repair regulator (TIRR) negatively regulates 53BP1 during DSB repair. Here, we present the crystal structure of the 53BP1 tandem Tudor domain (TTD) in complex with TIRR. Our results show that three loops from TIRR interact with 53BP1 TTD and mask the methylated lysine-binding pocket in...
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