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Article

Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission.

Journal of cardiovascular translational research - 1 Apr 2025

Lin Lin, Wei Jin, Xue Jiahong, Fan Gang, Zhu Wenjing, Zhu Yanhe, Wu Ruiyun

Abstract excerpt

Autoimmune myocarditis (AM) is characterized by an intricate inflammatory response within the myocardium. Dynamin-related protein 1 (Drp1), a pivotal modulator of mitochondrial fission, plays a role in the pathogenesis of various diseases. A myosin-induced experimental autoimmune myocarditis (EAM) mouse model was successfully established. Flow cytometry was employed to detect M1/M2-like macrophages. Mitochondrial...

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Identifiers

PMID: 39388091
DOI: 10.1007/s12265-024-10570-2

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