Role of Notch signalling pathway in cancer and its association with DNA methylation.

doi:10.1007/s12041-013-0284-5

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Article

Role of Notch signalling pathway in cancer and its association with DNA methylation.

Journal of genetics - 1 Dec 2013

Aithal Madhuri G S, Rajeswari Narayanappa

Abstract excerpt

The Notch signalling pathway is an evolutionarily conserved cell signalling pathway involved in the development of organisms as diverse as humans and fruit flies. It plays a pivotal role in cell fate determination. Dysregulated Notch signalling is oncogenic, inhibits apoptosis and promotes cell survival. Abnormal Notch signalling is seen in many cancers like T-cell acute lymphoblastic leukaemia, acute myeloid...

Topics

Animals
Antineoplastic Agents
CpG Islands
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Genetic Predisposition to Disease
Humans
Neoplasms
Oncogenes
Receptors, Notch
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 24371188
DOI: 10.1007/s12041-013-0284-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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