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Article

A solid-phase transfection platform for arrayed CRISPR screens.

Molecular systems biology - 1 Dec 2019

Serçin Özdemirhan, Reither Sabine, Roidos Paris, Ballin Nadja, Palikyras Spyridon, Baginska Anna, Rein Katrin, Llamazares Maria, Halavatyi Aliaksandr, Winter Hauke, Muley Thomas, Jurkowska Renata Z, Abdollahi Amir, Zenke Frank T, Neumann Beate, Mardin Balca R

Abstract excerpt

Arrayed CRISPR-based screens emerge as a powerful alternative to pooled screens making it possible to investigate a wide range of cellular phenotypes that are typically not amenable to pooled screens. Here, we describe a solid-phase transfection platform that enables CRISPR-based genetic screens in arrayed format with flexible readouts. We demonstrate efficient gene knockout upon delivery of guide RNAs and...

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Identifiers

PMID: 31885201
DOI: 10.15252/msb.20198983
PMCID: PMC6926425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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