Article

Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling Nonviral Genome Editing Efficiency

2025-03-14

Abstract excerpt

After administering genome editors, their efficiency is limited by a multi-step process involving cellular uptake, trafficking, and nuclear import of the vector and its payload. These processes vary widely across cell types and differ depending on the nature and structure of the vector, whether it is a lipid nanoparticle or a different synthetic material. We developed a novel genome-wide CRISPR screening strategy...

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Literature Corpus work: 72c0a84a-0a9c-5f7b-8b47-f844b8c6cb03
DOI: 10.1101/2025.03.12.642795

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