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Article

Microsecond molecular dynamics simulations reveal the allosteric regulatory mechanism of p53 R249S mutation in p53-associated liver cancer.

Computational biology and chemistry - 1 Feb 2020

Liu Xianxian, Tian Wenchao, Cheng Jinying, Li Dongmei, Liu Tonggang, Zhang Liguo

Abstract excerpt

The tumor suppressor p53, a transcription factor, plays a critical role in many cellular processes, including DNA repair and apoptosis and cell cycle arrest. Missense mutations in the p53 have closely related to human cancer. R249S mutation at the p53 core DNA binding domain (DBD) is frequently observed in hepatocellular carcinoma. This mutation is away from the p53 DBD-DNA binding interface. However, how the...

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Identifiers

PMID: 31881526
DOI: 10.1016/j.compbiolchem.2019.107194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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