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Article

R248Q mutation--Beyond p53-DNA binding.

Proteins - 1 Dec 2015

Ng Jeremy W K, Lama Dilraj, Lukman Suryani, Lane David P, Verma Chandra S, Sim Adelene Y L

Abstract excerpt

R248 in the DNA binding domain (DBD) of p53 interacts directly with the minor groove of DNA. Earlier nuclear magnetic resonance (NMR) studies indicated that the R248Q mutation resulted in conformation changes in parts of DBD far from the mutation site. However, how information propagates from the mutation site to the rest of the DBD is still not well understood. We performed a series of all-atom molecular...

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Identifiers

PMID: 26442703
DOI: 10.1002/prot.24940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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