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Article

Allosteric and Dominant-Negative Effects in a p53 Core Heterotetramer.

The journal of physical chemistry. B - 4 Dec 2025

Zhou Han, Zhou Tao, Yan Shiwei

Abstract excerpt

The tumor suppressor protein p53 is one of the most frequently mutated proteins in cancer cells and is a critical target for anticancer therapies. In the nucleus, the p53 core domain binds DNA response elements as a tetramer to regulate gene transcription. During early cancer development, mutant and wild-type p53 coexist and assemble into a heterotetramer. Experimental studies confirm that the R249S mutant exerts...

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PMID: 41271583
DOI: 10.1021/acs.jpcb.5c05859

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