Article
Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2015
Weiskopf Daniela, Bangs Derek J, Sidney John, Kolla Ravi V, De Silva Aruna D, de Silva Aravinda M, Crotty Shane, Peters Bjoern, Sette Alessandro
Abstract excerpt
Dengue virus (DENV) is a rapidly spreading pathogen with unusual pathogenesis, and correlates of protection from severe dengue disease and vaccine efficacy have not yet been established. Although DENV-specific CD8(+) T-cell responses have been extensively studied, the breadth and specificity of CD4(+) T-cell responses remains to be defined. Here we define HLA-restricted CD4(+) T-cell epitopes resulting from...
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