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Article

Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy.

Cellular and molecular life sciences : CMLS - 1 Feb 2013

Peche Vivek S, Holak Tad A, Burgute Bhagyashri D, Kosmas Kosmas, Kale Sushant P, Wunderlich F Thomas, Elhamine Fatiha, Stehle Robert, Pfitzer Gabriele, Nohroudi Klaus, Addicks Klaus, Stöckigt Florian, Schrickel Jan W, Gallinger Julia, Schleicher Michael, Noegel Angelika A

Abstract excerpt

Cyclase-associated proteins are highly conserved proteins that have a role in the regulation of actin dynamics. Higher eukaryotes have two isoforms, CAP1 and CAP2. To study the in vivo function of CAP2, we generated mice in which the CAP2 gene was inactivated by a gene-trap approach. Mutant mice...

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Identifiers

PMID: 22945801
DOI: 10.1007/s00018-012-1142-y
PMCID: PMC11113306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22945801-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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