Article

Loss of allosteric regulation in α-isopropylmalate synthase identified as an antimicrobial resistance mechanism

2022-12-07

Abstract excerpt

Despite our best efforts to discover new antimicrobials, bacteria have evolved mechanisms to become resistant. Resistance to antimicrobials can be attributed to innate, inducible, and acquired mechanisms. Mycobacterium abscessus is one of the most antimicrobial resistant bacteria and is known to cause chronic pulmonary infections within the cystic fibrosis community. Previously, we identified epetraborole as an i...

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Literature Corpus work: dcef16cc-4aab-5ef0-b36b-711d87435d63
DOI: 10.1101/2022.12.07.519492

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