Article
HflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria.
Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2021
Ngan Jie Yin Grace, Pasunooti Swathi, Tse Wilford, Meng Wei, Ngan So Fong Cam, Jia Huan, Lin Jian Qing, Ng Sze Wai, Jaafa Muhammad Taufiq, Cho Su Lei Sharol, Lim Jieling, Koh Hui Qi Vanessa, Abdul Ghani Noradibah, Pethe Kevin, Sze Siu Kwan, Lescar Julien, Alonso Sylvie
Abstract excerpt
GTPase high frequency of lysogenization X (HflX) is highly conserved in prokaryotes and acts as a ribosome-splitting factor as part of the heat shock response in Escherichia coli. Here we report that HflX produced by slow-growing Mycobacterium bovis bacillus Calmette-Guérin (BCG) is a GTPase that plays a critical role in the pathogen's transition to a nonreplicating, drug-tolerant state in response to hypoxia....
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