Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding.

doi:10.1016/j.mce.2018.01.006

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Article

Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding.

Molecular and cellular endocrinology - 15 Sept 2018

Benson Tyler W, Weintraub Daniel S, Crowe Matthew, Yiew Nicole K H, Popoola Orishebawo, Pillai Ajay, Joseph Joel, Archer Krystal, Greenway Charlotte, Chatterjee Tapan K, Mintz James, Stepp David W, Stansfield Brian K, Chen Weiqin, Brittain Julia, Bogdanov Vladimir Y, Gao Yan, Wilson James G, Tang Yaoliang, Kim Ha Won, Weintraub Neal L

Abstract excerpt

OBJECTIVE: Inflammation in adipose tissues in obesity promotes insulin resistance and metabolic disease. The Duffy antigen receptor for chemokines (DARC) is a promiscuous non-signaling receptor expressed on erythrocytes and other cell types that modulates tissue inflammation by binding chemokines such as monocyte chemoattractant protein-1 (MCP-1) and by acting as a chemokine reservoir. DARC allelic variants are...

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Identifiers

PMID: 29341885
DOI: 10.1016/j.mce.2018.01.006
PMCID: PMC6045443

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