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Article

Dectin-1 is required for beta-glucan recognition and control of fungal infection.

Nature immunology - 1 Jan 2007

Taylor Philip R, Tsoni S Vicky, Willment Janet A, Dennehy Kevin M, Rosas Marcela, Findon Helen, Haynes Ken, Steele Chad, Botto Marina, Gordon Siamon, Brown Gordon D

Abstract excerpt

Beta-glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the myeloid receptor for beta-glucan, rendered mice susceptible to infection with Candida albicans. Dectin-1-deficient leukocytes demonstrated significantly impaired responses to fungi even in the presence of opsonins. Impaired leukocyte...

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Identifiers

PMID: 17159984
DOI: 10.1038/ni1408
PMCID: PMC1888731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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