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Article

Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis

14 Nov 2022

Abstract excerpt

Subcutaneous phaeohyphomycosis typically affects immunocompetent individuals following traumatic inoculation. Severe or disseminated infection can occur in CARD9 deficiency or after transplantation, but the mechanisms protecting against phaeohyphomycosis remain unclear. We evaluated a patient with progressive, refractory Corynespora cassiicola phaeohyphomycosis and found that he carried biallelic deleterious...

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PMID: 36377664
DOI: 10.1172/jci159348

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