Article

Monocyte intrinsic NOD2 signalling inhibits pathogenic macrophage differentiation and its loss in inflammatory macrophages improves intestinal inflammation

2022-10-07

Abstract excerpt

<h4>Objective</h4> It is believed that intestinal recruitment of monocytes from Crohn’s Disease (CD) patients who carry NOD2 risk alleles may repeatedly give rise to recruitment of pathogenic macrophages. We investigated an alternative possibility that NOD2 may rather inhibit their differentiation from intravasating monocytes. <h4>Design</h4> The monocyte fate decision was examined by using germ-free mice, mixed...

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Literature Corpus work: b16e0bd6-ae52-5f6e-be40-fe195b718793
DOI: 10.1101/2022.10.06.506772

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