Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The stem cell–specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia

22 Dec 2019

Abstract excerpt

HOX genes are highly conserved, and their precisely controlled expression is crucial for normal hematopoiesis. Accordingly, deregulation of HOX genes can cause leukemia. However, despite of intensive research on the coding HOX genes, the role of the numerous long noncoding RNAs (lncRNAs) within the HOX clusters during hematopoiesis and their contribution to leukemogenesis are incompletely understood. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Cytokine Signaling Pathways and Interactions
Share to Mycobacterium research and diagnosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31867596
DOI: 10.1182/bloodadvances.2019032029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The stem cell–specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemiaPMID 31867596Read ↗

Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.Semantic proximity Read ↗

Acute Myeloid Leukemias with Alterations of Lysine Methyltransferase 2A (KMT2A): Recent Therapeutic DevelopmentsSemantic proximity Read ↗

Luks-PV induce HOXA9 degradation through autophagy in Acute myeloid leukemia with HOXA9 overexpressionSemantic proximity Read ↗

Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemiaSemantic proximity Read ↗

Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation.Semantic proximity Read ↗

Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis.Semantic proximity Read ↗

HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.Semantic proximity Read ↗

Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemiaSemantic proximity Read ↗

Functional Interrogation of <i>HOXA9</i> Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screenSemantic proximity Read ↗

Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia.Semantic proximity Read ↗

lncRNA HOXA-AS2 functions as an oncogene by binding to EZH2 and suppressing LATS2 in Acute myeloid leukemia (AML)Semantic proximity Read ↗

NPM1 mutation mediated HOXBLINC lncRNA activation promotes AML leukemogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.