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Article

Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia.

The Journal of biological chemistry - 23 Jan 2009

Wang Hao, Lindsey Stephan, Konieczna Iwona, Bei Ling, Horvath Elizabeth, Huang Weiqi, Saberwal Gurveen, Eklund Elizabeth A

Abstract excerpt

The homeodomain transcription factor HoxA10 is maximally expressed in myeloid progenitor cells. Sustained HoxA10 expression during differentiation has been described in poor prognosis human acute myeloid leukemia (AML). Consistent with this, engineered overexpression of HoxA10 in murine bone marrow induces a myeloproliferative disorder that progresses to AML over time. This murine model suggests that HoxA10...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19022774
DOI: 10.1074/jbc.M804704200
PMCID: PMC2629090

Genes

DUSP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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