Article

xCell 2.0: Robust Algorithm for cell type Proportion Estimation Predicts Response to Immune Checkpoint Blockade

2024-09-10

Abstract excerpt

<h4>Background: </h4> Accurate estimation of cell type proportions from bulk gene expression data is essential for understanding the cellular heterogeneity underlying complex tissues and diseases. Here, we introduce xCell 2.0, an advanced version of the xCell algorithm, featuring a training function that permits the utilization of any reference dataset. xCell 2.0 generates cell type gene signatures using an improv...

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Literature Corpus work: adf39c8c-9c44-50b6-8005-21da91567404
DOI: 10.1101/2024.09.06.611424

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